Hyaluronic acid - advanced wound healing

Sodium hyaluronate (HA) plays several key roles during the wound healing process. In the initial wound, sodium hyaluronate binds to fibrin and fibrinogen, contributing to clot formation and enhancing the migration of inflammatory cells (macrophages, etc).

Hyaluronic acid benefits in wound care

Sodium hyaluronate synthesis is up-regulated at sites of tissue injury (i.e., during wound healing). HA accumulation is enhanced immediately after injury and remains elevated during the inflammatory and early granulation/re-epithelialization stages of wound repair.

• Sodium hyaluronate has multiple functions during topical wound repair, particularly in the inflammatory and early granulation stages. HA interacts with fibrin clots and initially modulates host inflammatory cell infiltration into the inflamed site.
• Sodium hyaluronate induces production of growth factors and cytokines in inflammatory cells, fibroblasts and keratinocytes, and protects and presents growth factors involved in topical wound repair, such as Platelet-derived growth factor (PDGF) and Vascular endothelial growth factor (VEGF), to their cognate receptors.

 

Hyaluronic acid for accelerated wound healing

HA acts as an antioxidant by scavenging radical oxygen species (ROS) from inflammatory cells, and thus functions to both stimulate and limit inflammation at the wound site. During the formation of granulation tissue, HA promotes migration of both keratinocytes and fibroblasts, regulates cell proliferation, and contributes to the structure of the provisional matrix of granulation tissue